CRITICA (Coding Region Identification Tool Invoking Comparative Analysis) is a program for identifying the protein coding regions in DNA based on a combination of evidence from dicodon usage frequencies and a comparative analysis of the relative conservation of DNA sequence and their potential protein products.
CRITICA is described in the paper:
Badger, J. H., and Olsen, G. J. 1999. CRITICA: Coding region identification tool invoking comparative analysis. Mol. Biol. Evol. 16: 512–524. (PubMed; Oxford Journals)
For the time being, the directory CRITICA contains an unofficial release (1.0.5b) of the program and documentation files that includes a bug fix for about 1/3 of the reading frames that run off the end of a contig (something that matters more for partial genome projects than for completed genomes).
In general, the directory critica contains the current release of the program and documentation files. If anyone notices a version newer than 1.0.5 (01-Aug-2000) appearing at this site, please E-mail me so that I can remove the link above.
Gary
Return to Programs PagePage written and maintained by Gary J. Olsen (gjo☮illinois.edu)