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Bettina Francis I
came into the department in 1997 from the Institute for Environmental Studies. My
connections to the department are much deeper, however, since I worked for Bob Metcalf
from 1978 to 1981 (on projects ranging from the delayed neurotoxicity of leptophos and
developmental toxicity of azinphosmethyl, to integrated pest management for home and
garden) and continued to work with him thereafter. My research in pesticide toxicology has
ranged from structure-activity relationships in the delayed neurotoxicology of
organophosphate ester insecticides to the developmental toxicity of diphenyl ether
herbicides, which is my current interest. Certain diphenyl ethers, including the herbicide
nitrofen, cause an unusual constellation of malformations in mice and rats. The nature of
the malformations strongly suggests that these compounds act on expression of
developmentally specific genes. Identifying these genes is my current goal. I also have an
ongoing interest in the environmental toxicity of synthetic chemicalsthat is, in
their effects on species other than humans and livestock. One course I teach, Toxic
Substances in the Environment (ENT 331), is an overview of both the ecological and human
health effects of environmental pollutants. The Wiley volume by the same name is being
updated for a second edition. The class notes for the second course I teach, Pesticide
Toxicology (ENT 333), will eventually become a book as well. |